Abstract
Summary
Pretreatment with hydrocortisone restores plasma NEFA response of adrenalectomized animals to normal but is without effect on intact rats. Pretreatment with guanylic acid, a purine nucleotide, abolishes NEFA response to fasting and tourniquet stress in the normal animal. It prevents elevation in plasma NEFA in the fasting adrenalectomized rats. Survival time of adrenalectomized animals subjected to tourniquet stress is significantly prolonged by pretreatment with guanylic acid. A physiologic mechanism is suggested which operates via lymphatic release of nucleotides resulting from cortical steroid activity.
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