Abstract
Summary
The biologic half-life of free 11-desoxycortisol in circulating plasma of man. estimated as Porter-Silber chromogens, was 42 min. This may be prolonged to as much as 80 min. in the presence of liver disease or to 108 min in hypothyroidism. Absence of an 11-beta hydroxyl group accelerates clearance of 11-desoxycortisol from plasma, its removal rate being twice as rapid as that of cortisol. 11-Desoxycortisol is rapidly conjugated to a glucuronide. Concentration of its Porter-Silber chromogen metabolites is 5 times greater than that of cortisol at comparable peak levels; the glucuronide conjugates of both steroids disappear from plasma with a half-time of 102 min.
Get full access to this article
View all access options for this article.