Abstract
Summary
1. Mephenesin is oxidatively metabolized in vitro by rat and mouse liver slices to 3-(o-tolyloxy) lactic acid. 2. Mephenesin metabolism was markedly inhibited by increasing substrate concentration, but was not altered by presence of increasing concentrations of the product, 3-(o-tolyloxy)lactic acid, in the medium. 3. Metabolism of mephenesin was readily inhibited by iodoacetic acid, but was unaltered by aldehyde trapping agents at 10-3 M.
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