Abstract
Summary
1. There is a marked increase in intestinal lymph flow of the dog following injection of E. coli endotoxin, and also after partial obstruction of the portal vein. 2. The magnitude of the rise in lymph flow after endotoxin is not significantly correlated with the rise in portal venous pressure. But there is a highly significant correlation between the absolute portal venous pressure level during obstructive elevation and the percentage change in lymph flow. There is a similarly significant correlation between the percentage change in lymph flow per unit rise in portal pressure and the absolute level of portal vein pressure. 3. The increased lymph flow after injection of endotoxin can not be accounted for on the basis of the elevation in portal venous pressure but perhaps is due to the action of substances liberated by some chemical effect of endotoxin which influence lymph flow through some mechanism other than one acting through rise in portal venous pressure.
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