Abstract
Summary
One to 3 injections of 40 units of ACTH-gel significantly enhanced the elevated serum cholesterol and phospholipid levels produced by subsequent thiouracil and cholesterol feeding in the dog. This effect was associated with paralytic strokes in 4 of 10 dogs. Autopsy revealed markedly more widespread and more severe atherosclerosis in dogs pretreated with ACTH than in dogs who received only a high thiouracil and cholesterol diet.
The authors are indebted to Drs. Wilfrid Dixon and Frederick Moore for statistical evaluation of the data and Drs. John Mehl and Ross Jacobs for supervision of lipid and lipoprotein determinations.
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