Abstract
Summary and conclusions
1) Bishydroxycoumarin-induced hypoprothrombinemia may result in a slight delay of fibrin clot in isolated venous segments of anesthetized dogs. 2) The hemorrhagic state produced by the drug fails to prevent acceleration of intravascular clotting caused by intravenous infusion of fat emulsion. This clot acceleration, therefore, may not operate through the mechanism of prothrombin conversion. 3) Our experiments lend support to the concept that anticoagulation with coumarin-type drugs is not synonymous with antithrombotic effect.
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