Abstract
Summary
The normal rabbit, treated with hypoglycemic doses of phenethylbiguanide, shows a significant increase in serum inorganic phosphate levels. In this respect the action of phenethylbiguanide differs from that of insulin and sulfonylurea oral hypoglycemic agents, and closely resembles that of structurally related diguanidine, Synthalin A. Increase in serum inorganic phosphorus levels is consistent with inhibition of oxidative enzyme systems of the citric acid cycle in presence of phenethylbiguanide, which suggests that inorganic phosphorus might escape into the blood stream due to decreased binding of high energy phosphorus.
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