Abstract
Summary
Rat liver slices convert methioprim to 2-methylthio-4-amino-5-formylpyrimidine and 2-methylthio-4-amino-5-pyrimidine-carboxylic acid. Another unidentified ultraviolet-absorbing material is also produced. The antibacterial activity of methioprim is greater than the 5-CHO derivative, whereas the 5-COOH derivative is inactive.
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