Labile Phosphate Changes in Ileum of the Rat

Abstract

Summary

1. Both muscularis and mucosa of rat show significant changes in amounts of energy-rich phosphate compounds when animal is fasted or fasted and briefly fed. 2. With increasing periods of starvation to 72 hours, the easily hydrolyzable phosphate compounds, Cr.P.-P. and A.T.P.P., diminish in both tissues in a predictable manner. 3. The mucosa appears to be more labile of the 2 tissues, although the muscularis shifts in the same direction and to nearly the same magnitude. 4. The assay of either Cr.P.-P. or A.T.P.P. on whole intestinal segments will provide sufficient data as would the independent assay of each, in the major tissues comprising the intestine, to follow the nature of the mechanism involved.