Abstract
Summary
The fate of a cholesterol meal containing 10 μc of cholesterol-4-C14 was compared in untreated and cortisone treated, cholesterol-fed rabbits on their regime for 14 days. Plasma free and ester cholesterol specific activity were followed during 48 hours after the fed labeled cholesterol meal, and then animals were killed. Terminal concentrations of free and ester cholesterol in plasma and in liver of cortisone treated, were significantly lower than the respective values in untreated. The free and ester cholesterol specific activity of plasma, liver, ileum and aorta of cortisone treated were 40–60% lower than that of untreated animals. It was concluded that cortisone injection of cholesterolfed rabbits caused a change in behavior of ingested cholesterol. Further studies will be necessary to elucidate the mechanism of cortisone action.
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