Serum Lipid,Lipoprotein and Vascular Tissue Studies in Cholesterol-Fed Horse. ∗

Abstract

Summary

A diet containing 1.7 ' 2% cholesterol did not alter serum lipid or lipoprotein levels when fed to a gelded horse for 3 months. When cholesterol supplementation was discontinued, significant increases in serum total and free cholesterol, lipid phosphorus, C/P ratio and high density -S1.₂₁ 0-₂₀ (“alpha”) lipoproteins occurred which persisted until sacrifice 3 months later. Fecal lipid analyses indicated net cholesterol absorption in excess of 70%. Liver and aortic lipid analyses and histologic examination of myocardium, coronary arteries and aorta were not remarkable.