Abstract
Summary
(1) TAM (Transforming Agent Myxoma) became susceptible to destructive action of DNase when treated with urea. (2) DNase used under same conditions had no effect on TAM prepared by heat alone. (3) RNase did not destroy UREA-TAM. (4) Potency of UREA-TAM was comparable to that of heated TAM from which it was prepared. (5) Evidence accumulated indicated that myxoma DNA is intimately concerned with transformation of fibroma into myxoma virus in tissue culture.
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