Abstract
Summary
Oral administration of collidine derivative (Diethyl 1, 4-dihydro-2, 4, 6-tri-methylpyridine-3, 5-dicarboxylate) to mice produces a disturbance in porphyrin metabolism characterized by marked increases in hepatic proto- and coproporphyrin. Red fluorescence of kidneys of animals treated with this agent for 7 days is associated with great increase in renal protoporphyrin and smaller increase in renal uroporphyrin. In the guinea pig, oral administration of collidine derivative produced high levels of urinary copropor-phyrin and trace amounts of urinary porphobilinogen.
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