Disturbance in Porphyrin Metabolism Caused by Feeding Diethyl 1,4-dihydro-2,4,6-trimethylpyridine-3,5-dicarboxylate

Abstract

Summary

Oral administration of collidine derivative (Diethyl 1, 4-dihydro-2, 4, 6-tri-methylpyridine-3, 5-dicarboxylate) to mice produces a disturbance in porphyrin metabolism characterized by marked increases in hepatic proto- and coproporphyrin. Red fluorescence of kidneys of animals treated with this agent for 7 days is associated with great increase in renal protoporphyrin and smaller increase in renal uroporphyrin. In the guinea pig, oral administration of collidine derivative produced high levels of urinary copropor-phyrin and trace amounts of urinary porphobilinogen.