Effect of Dietary Iron on Phosphate Metabolism. ∗

Abstract

Conclusions

Increasing the amount of iron by means of stomach tubing FeSO₄ to rats significantly increases liver iron content. When 50 mg phosphate is given simultaneously with iron, a significant reduction in liver iron content results, as well as a significant diminution in calcium and phosphorus content of newly forming incisor dentin. These results, compared with a significant reduction in blood phosphorus concentration, suggest that increasing the iron content of the diet for prolonged periods of time without significantly increasing the dietary phosphorus content may result in improperly calcified tissues.