Translocation of Radioactive Silver Compounds from Site of Injection into Organs. ∗

Abstract

Summary and conclusions

1) Data were obtained in mice on translocation of 5 radioactive silver Ag¹¹¹ compounds at various intervals after injection into the tail by a previously described method of serial tail amputations and 24 hours after injection into the scalp. 2) Ag¹¹¹ nitrate storage rate at site of injection was higher than for another soluble compound—Ag¹¹¹ lactate, but lower than for 2 insoluble coarsely particulate compounds—Ag¹¹¹ oxide and chloride; on the contrary, pick-up by liver and blood was highest for soluble compounds. 3) Translocation of each compound from the scalp followed the pattern of its translocation from the tail but at a much slower rate. 4) In the above experimental conditions the fate of various Ag¹¹¹ compounds in the body of the mouse depended mainly a) on the physico-chemical properties of the compound (solubility, pH, ability to form colloidal complexes with tissue fluid and blood, size and tendency of insoluble particles to clump) and b) on biological conditions at site of injection. 5) The planned use of this method in tumor-bearing mice is presumed to be helpful for selection of the choice compound for local or systemic therapeutic application.