On some vaccinia blood pressor substances in rabbits

Abstract

Summary

1. Depressor and pressor substances arise after vaccinia infection in the blood-serum of rabbits. 2. Aging tends to eliminate the depressor substance and a pressor substance then comes in evidence.

Note.-A serum obtained from a rabbit after streptococcus infection, which had 12 months previously given a profound depressor reaction was also tested (3-18-13) and was found to give no reaction. 8 C.C. of a saline extraction of the adrenals of a 30 day vaccinia rabbit, gave (3-28-13) no reaction. This extraction was made in 20 C.C. of physiological saline solution and was kept 6 days in the ice-box. 7 C.C. of a saline extraction of the adrenals of a two day vaccinia rabbit gave (3-8-13) a fine rise followed by a marked fall. This extraction was made in 20 C.C. and was kept 24 hrs. in the ice-box, i. e., since immediately after removal.