1. Keech AC, Mitchell P, Summanen PA et al. Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial. Lancet 2007; published on-line on 6 November. DOI: 10.1016/S0140-6736(07)61607-9.
2.
2. www.idf.org. Accessed November 2007.
3.
3. Gregg EWGu Q, Cheng YJet al.Mortality trends in men and women with diabetes, 1971–2000. Ann Intern Med2007;147:149–55.
4.
4. Lipscombe LLHux EJ.Trends in diabetes prevalence, incidence, and mortality in Ontario, Canada 1995–2005: a population-based study. Lancet2007;369:750–6.
6. Wong TYKlein R, Islam FMet al.Diabetic retinopathy in a multi-ethnic cohort in the United States. Am J Ophthalmol2006;141:446–55.
7.
7. Cusick MMeleth AD, Agron Eet al.Associations of mortality and diabetes complications in patients with type 1 and type 2 diabetes: early treatment diabetic retinopathy study report no. 27. Diabetes Care2005;28:617–25.
9. Diabetes Prevention Program Research Group.The prevalence of retinopathy in impaired glucose tolerance and recent-onset diabetes in the Diabetes Prevention Program. Diabetic Med2007;24:137–44.
10.
10. Turner RCCull CA, Frighi V, Holman RR.Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA1999;281:2005–12.
11.
11. Gaede PVedel P, Larsen Net al.Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med2003;348:383–93.
12.
12. Aiello LM.Perspectives on diabetic retinopathy. Am J Ophthalmol2003;136:122–35.
13.
13. Cunningham ETAdamis AP, Altaweel Met al.A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema. Ophthalmol2005;112:1747–57.
14.
14. Jorge RCosta RA, Calucci Det al.Intravitreal bevacizumab (Avastin) for persistent new vessels in diabetic retinopathy (IBEPE study). Retina2006;26:1006–13.
15.
15. Keech ASimes RJ, Barter Pet al.Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet2005;366:1849–61.
16.
16. Burgess DHunt D, Li LPet al.Effects of fenofibrate on silent myocardial infarction, hospitalization for acute coronary syndromes and amputation in type 2 diabetes: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Circulation2007;116:II-838 (Abstract 3693).
17.
17. ETDRS Group.Early photocoagulation for diabetic retinopathy. ETDRS report number 9. Ophthalmology1991;98:766–85.
18.
18. ETDRS Group.Grading diabetic retinopathy from stereoscopic color fundus photographs: an extension of the modified Airlie House classification. ETRDS report number 10. Ophthalmology1991;98:786–806.
19.
19. Meleth ADAgrón E, Chan CCet al.Serum inflammatory markers in diabetic retinopathy. Invest Ophthalmol Vis Sci2005;46:4295–301.
20.
20. Lyons TJJenkins AJ, Zheng Det al.Diabetic retinopathy and serum lipoprotein subclasses in the DCCT/EDIC cohort. Invest Ophthalmol Vis Sci2004;45:910–18.
21.
21. Chapman MJ.Fibrates in 2003: therapeutic action in atherogenic dyslipidaemia and future perspectives. Atherosclerosis2003;171:1–13.
22.
22. Kim JAhn JH, Yu YSet al.Fenofibrate regulates retinal endothelial cell survival through the AMPK signal transduction pathway. Experimental Eye Res2007;84:886–93.
23.
23. Goetze SEilers F, Bungenstock Aet al.PPAR activators inhibit endothelial cell migration by targeting Akt. Biochem Biophys Res Comm2002;293:1431–7.
24.
24. Demircan NSafran BG, Soylu Met al.Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy. Eye2006;20:1366–9.
25.
25. Ryan KEMcCance DR, Powell Let al.Fenofibrate and pioglitazone improve endothelial function and reduce arterial stiffness in obese glucose tolerant men. Atherosclerosis2007;194:e123–e130.
26.
26. Losada MAlio LJ.Malondialdehyde serum concentrations in type 1 diabetics with and without retinopathy. Documenta Ophthalmologica1997;93:223–9.
27.
27. Skrha JStulc T, Hilgertová Jet al.Effect of simvastatin and fenofibrate on endothelium in Type 2 diabetes. Eur J Pharmacol2004;493:183–9.
28.
28. Chew EYKlein ML, Ferris FL 3rdet al.Association of elevated serum lipid levels with retinal hard exudate in diabetic retinopathy. Early Treatment Diabetic Retinopathy Study (ETDRS) Report 22. Arch Ophthalmol1996; 114:1079–84.
29.
29. Zhang JMcGwin GAssociation of statin use with the risk of developing diabetic retinopathy. Arch Ophthalmol2007;125:1096–9.
30.
30. Ansquer JCFoucher C, Rattier Set al.Fenofibrate reduces progression to microalbuminuria over 3 years in a placebo-controlled study in type 2 diabetes: Results from the Diabetes Atherosclerosis Intervention Study (DAIS). Am J Kidney Dis2005;45:485–93.
31.
31. Scott Rd'Emden M, Best Jet al.Features of metabolic syndrome identify individuals with type 2 diabetes mellitus at high risk for cardiovascular events and greater absolute benefits of fenofibrate. Circulation2007;116:II_838 (Abstract 3691).