Leucrose, D-glucopyranosyl-α(l 5)-D-fructopyranose, is produced by treatment of sucrose with the α(1 6)-glucosyltransferase isolated from Leuconostoc mesenteroides, a nonpathogenic, nontoxigenic microorganism. Rats, dogs, and humans metabolize leucrose efficiently and rapidly in the jejunum by enzymatic hydrolysis into its constituent glucose and fructose. Only traces of leucrose appear in plasma and urine of rats and humans, whereas somewhat larger amounts are seen in plasma and urine of dogs. No toxic or other biological effects were detected in 13-week studies in rats and dogs. Leucrose is not teratogenic in rats and rabbits, and is not genotoxic. It is noncariogenic in humans and rats, and resists attack by the microorganisms present in the human oral cavity.
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LPT. (1992d) Examination of the influence of leucrose, a binding isomer of saccharose on the pregnant rabbit and the foetus by oral administration. Project 4878/88 submitted by the Laboratory of Pharmacology and Toxicology, Hamburg, Germany, Jun 19.
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SRI International. (1995a) Salmonella/microsome plate incorporation assay of leucrose. Menlo Park, CA: SRI, report LSR 6212–200, Jan 23.
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SRI International. (1995b) Bone marrow erythrocyte micronucleus assay of leucrose in Swiss-Webster mice. Menlo Park, CA: SRI, report 6212–C500–94, Feb 9.
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SRI International. (1995c) Measurement of chromosomal damage in Chinese hamster ovary (CHO) cells treated with leucrose. Menlo Park, CA: SRI, report 6212–C400–94, Feb 27.
26.
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