Tara gum is a potential replacement for locust bean gum for use as a formulation aid, stabilizer, and thickener for food applications. In addition to biochemical and digestibility data, studies assessing the toxicity of tara gum are reviewed. The latter includes three 90-day feeding studies, two in rats and one in dogs; two 2-year feeding studies in rats and one in mice; a 3-generation reproduction study with rats and a reproductive toxicity and teratogenicity study with rats; an Ames reverse mutation assay with five Salmonella typhimurium strains; and a micronucleus test in mice. The feeding studies did not indicate any significant adverse effects attributable to tara gum at the maximum dietary level of 5%. The results of the genotoxicity studies were negative. It is concluded that tara gum meets the scientific standards required for classification as a GRAS food ingredient.
References
1.
Glicksman, M. (1986a). Tara gum, in: Food Hydrocolloids. Vol. III. M. Glicksman. Boca Raton, Fl: Crc Press, pp. 186–189.
2.
Glicksman, M. (1986b). Guar gum, in: Food Hydrocolloids. Vol. III. M. Glicksman. Boca Raton, Fl: Crc Press, pp. 172–184.
3.
Glicksman, M. (1986c). Locust bean gum, in: Food Hydrocolloids. Vol. III. M. Glicksman. Boca Raton, Fl: Crc Press, pp. 162–170.
4.
OMS. WHO. (1976). Additifs Alimentaires Nr 7. OMS: OMS.
5.
Anderson, E. (1949). Endosperm mucilages of legumes—occurrence and composition. Ind. Eng. Chem.41(12):2887–2890.
6.
Rahanitrinianina, D., Artaud, J., Iatrides, M.C., Gaydou, E.M. (1984). Chemical composition of tara (Caesalpinia spinosa, Caesalpiniacease) seeds. I-fatty acids and sterols. Rev. Fr. Corps. Gras31(6):249–252.
7.
Dea, I.C.M., Morris, E.R., Rees, D.A., Welsh, E.J., Barnes, H.W., and Price, J. (1987). Associations of like and unlike polysaccharides: Mechanism and specificity in galactomannans, interacting bacterial polysaccharides and related systems. Carbohydr. Res.57:273–280.
FAO/WHO. (1987). WHO Food Additive Series 21. Toxicological evaluation of certain food additives and contaminants V+282 p. Cambridge: Cambridge University Press.
10.
NRC. (1989). 1987 Poundage update of food chemicals. NTIS No. PB84–162148. Washington, D.C: National Research Council Committee on Food Additives Surveys.
11.
SUBCOMMITTEE ON REVIEW OF GRAS LIST (Phase II). (1972). A comprehensive survey of industry on the use of food chemicals generally regarded as safe (GRAS). Prepared under DHEW contract no. FDA 70–22 by the Committee on Food Protection, Division of Biology and Agriculture. Washington, D.C: National Research Council, National Academy of Sciences.
12.
Pao, E.M., Fleming, K.H., Guenther, P.M., and Mickle, S.J. (1982). Foods commonly eaten by individuals: Amount per day and per eating occasion. Home Economics Report No. 44. U.S. Department of Agriculture. Superintendent of Documents. Washington, D.C: U.S. Government Printing Office.
13.
CODE OF FEDERAL REGULATIONS. Title 21. Food and Drugs. Parts 100 to 199, 184, 1343. (1989). Office of the Federal Register. Washington, D.C: General Services Administration.
14.
National Toxicology Program (1982). NTP Technical Report on the Carcinogenesis Bioassay of Tara Gum in F344 Rats and B63Fl Mice. NTP TR 224. Research Triangle Park, NC: National Institute of Environmental Health Sciences.
15.
Semenza, G. (1975). The possible digestion of tara gum in the stomach and/or in the small intestine. An in vitro study. Unpublished report. Zurich: Laboratorium fur Biochemie, Eidgenossische Technische Hochschule.
16.
Towle, G.A. and Schranz, R.E. (1975). The action of rat microflora on tara gum solutions in vitro. Unpublished report. Wilmington, De: Hercules, Inc.
17.
Barry, J.L., Bonnet, C., David, A., and Koslowski, F. (1990). Measurement of the digestibility of tara galactomannans in rats. Unpublished report Bp 527. Nantes, France: l'Institut national de la Rècherche Agronomique Laboratoire de Technologie Appliquée a la Nutrition.
18.
Tsai, L.B. and Whistler, R.L. (1975). Digestibility of galactomannans. A one-page summary of report was available. Unpublished report. Lafayette, In: Department of Biochemistry, Purdue University.
19.
Rice, E.E. (1957). Comparisons of the metabolic energy contributions of foods by growth under conditions of energy restrictions. J Nutr61:253–266.
20.
WARF INSTITUTE. (1973). Bioavailable calorie assay. Unpublished report. Madison, WI: WARE Institute.
21.
Til, H.P., Spanjers, M.T., and Degroot, A.P. (1974). Sub-chronic study with tara gum in rats. Unpublished report from Centraal Instituut voor Voedingsonderzoek, Tno, to Hercules, Inc. Summary of report was given in “A report to the Tara Gum Development Group. Areviewofthetoxicological data base for tara gum” by J.J. Domanski, Jr. Wilmington, De: Hercules, Inc.
Oshita, G., et al. (1975). 90-Day subchronic oral toxicity study with tata gum in beagle dogs. Summary was given in “A report to the Tara Gum Development Group. A review of the toxicological data base for tara gum” by J.J. Domanski. Unpublished report. Wilmington, De: Hercules, Inc.
24.
INDUSTRIAL BIO-TEST LABORATORIES, INC. (1980) Northbrook, IL. Two-year chronic toxicity study with tara gum in albino rats. Unpublished report of study conducted under contract with the Tara Development Group and monitored (and found acceptable) by W.A. Carlson (scientific consultant), J.J. Domanski, Jr., (Hercules, Inc., Wilmington, DE); P.H. Errico, M.A. Hoover, and C. Rose, (Tracor Jitco, Inc., Rockville, MD).
25.
Domanski, J.J., Jr., Carlson, W., and Frawley, J. (1980). Three-generation reproduction study with tara gum in albino rats. Unpublished report. Wilmington, De: Hercules, Inc.
26.
Becker, H., Schanfroth, P., Terrier, C., and Sachsse, K. (1986). Embryotoxicity (including teratogenicity) study with tara gum in the rat. Unpublished report no. 53335. Itingen, Switzerland: Research and Consulting Company Ag.
27.
Boeuf, C., Bonafous, J., Vanrell, B., Glomot, R., and Lebigot, J.F. (1988). Tara gum. Reverse mutation assay in vitro. Ames test. Unpublished report. Miserey, France: le Centre International de Toxicologie (C.I.T.).
28.
Vanrel, B., Glomot, R., and Lebigot, J.F. (1988). Tara gum. Micronucleus test in mice. Unpublished report. Miserey, France: Centre International de Toxicologie (C.I.T.).
29.
FDA. (1982). Toxicological principles for the safety assessment of direct food additives and color additives used in food. Report PB83–170696. Available from NTIS, Springfield, VA.
30.
Degnan, F.H. (1991). Rethinking the applicability of usefulness of the Gras concept. Food Drug Cosmetic Law J.46:553–582.
