Zinc Phenolsulfonate is a substituted phenol used in cosmetic products as an antimicrobial and astringent at concentrations up to 5%. This compound was moderately toxic when administered orally. No deaths or growth inhibition were reported in a 91-day rat feeding study. No significant toxicity was reported when Zinc Phenolsulfonate was applied dermally in acute and sub-chronic studies. A single insult patch test of a 5% aqueous Zinc Phenolsulfonate solution was negative for skin irritation in rabbits. Minimal skin irritation was reported when 100% Zinc Phenolsulfonate was tested. The Buehler test for delayed sensitization was negative. No eye irritation was observed in rabbits exposed to 5% aqueous Zinc Phenolsulfonate and only moderate irritation at 100%.
No mutagenicity was observed when Zinc Phenolsulfonate was tested with and without metabolic activation in five Salmonella strains.
Clinical assessment of Zinc Phenolsulfonate with product formulations indicated that Zinc Phenolsulfonate was at most a mild skin irritant in normal use, but not a sensitizer. It is concluded that Zinc Phenolsulfonate is safe as a cosmetic ingredient in the present practices of use and concentration.
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