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Abstract

Objective: To test the efficacy of clozapine in treatment-resistant manic episodes.

Clinical picture: Three cases, two with bipolar disorder (manic) and one of schizoaffective disorder (manic), were treated with clozapine.

Treatment: Clozapine was used after the failure of standard antipsychotics and mood stabilisers.

Outcome: All three cases were successfully treated.

Conclusion: A controlled trial of clozapine in treatment-resistant bipolar and schizoaffective manic episodes is indicated.

Keywords

bipolar manic schizoaffective treatment-resistant

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Clozapine in the Management of Bipolar and Schizoaffective Manic Episodes Resistant to Standard Treatment

Abstract

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