Objective: To report a case of clozapine-induced hypertension with raised urinary catecholamines.
Clinical picture: A 27–year-old man fulfilling DSM-Ill-R criteria for catatonic schizophrenia was treated with clozapine. He later developed both hypertension and raised urinary catecholamines which mimicked phaeochromocytoma.
Treatment: Clozapine was withdrawn.
Outcome: Both blood pressure and urinary catecholamines normalised.
Conclusions: Clozapine may induce sympathetic hyperactivity.
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