Kleine-Levin Syndrome is an unusual sleep disorder occurring predominantly, but not exclusively, in late adolescent males. A case is described which illustrates some of the difficulties in diagnosis and management.
References
1.
ThompsonCObrechtRFraneyJArendtJCheckleySA. Neuroendocrine rhythms in a patient with the Kleine-Levin syndrome. British Journal of Psychiatry1985; 147: 440–443.
LevinM. Narcolepsy and other varieties of morbid somnolence. Archives of Neurology and Psychiatry1929; 22: 1172–1200.
4.
WallerDAJarrielSErmanMEmslieG. Recognizing and managing the adolescent with Kleine-Levin syndrome. Journal of Adolescent Healthcare1984; 5: 139–141.
5.
ParkesJD. The Kleine-Levin syndrome in sleep and its disorders. London: WB Saunders, 314–320.
6.
CritchleyM. Periodic hypersomnia and megaphagia in adolescent males. Brain1962, 85: 627–56.
7.
JeffriesJJLefebvreA. Depression and mania associated with Kleine-Levin-Critchley syndrome. Canadian Psychiatric Association Journal1973; 18: 439–444.
8.
JovanovicMJ. Die wichtigsten abnormen Schlaf syndrome. In: JovanovicU.J.BarthJ.A., eds. Der Schlaf neurophysiologische aspekte. Munich: 1969: 223–231.
9.
WillRGYoungJPRThomasDJ. Kleine-Levin syndrome: report of two cases with onset of symptoms precipitated by head trauma. British Journal of Psychiatry1988; 152: 410–412.
10.
OswaldI. Sleep and its disorders. In: VinklerPJBruynGW. Handbook of clinical neurology, Vol. 3. Amsterdam: 1969: 80–111.
11.
TakrainLCroninD. Kleine-Levin syndrome in a female patient. Canadian Psychiatric Association Journal1976; 21: 315–318.
12.
CarpenterSYassaROchsR. A pathological basis for Kleine-Levin syndrome. Archives of Neurology1982; 39: 25–8.
13.
GoldbergMA. The treatment of Kleine-Levin syndrome with lithium. Canadian Journal of Psychiatry1983; 28: 491–493.
HelenChiu FJWahLi Siu Lee Sing. Kleine-Levin syndrome 15 years later. Australian and New Zealand Journal of Psychiatry1989; 23: 425–427.
16.
BurtonS. Recovery from “Sleep Attacks” in Kleine-Levin syndrome may involve a process of gradual phase advance. Sleep Research1989; 18: 209.
17.
KoerberRKTprkelsonRHavenGDonaldsonJCohenSMCaseM. Increased cerebrospinal fluid 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in Kleine-Levin syndrome. Neurology1984; 34: 1597–600.
18.
ThompsonCObrechtRFraneyCArendtJCheckleySA. Neuroendocrine rhythms in a patient with the Kleine-Levin syndrome. British Journal of Psychiatry1985; 147: 440–3.
19.
GadothNDickermanZBecharMLaronZLavieP. () Episodic hormone secretion during sleep in Kleine-Levin syndrome: evidence for hypothalamic dysfunction. Brain and Development1987; 3: 309–315.
20.
TaylorPLGarickNABurnsRSTamarkinLMurphyDLMarkeySP. Diurnal rhythms of serotonin in monkey cerebrospinal fluid. Life Science1982; 31: 1993–1999.
21.
OguraCOkumaTNakazewaKKishimoto. Treatment of periodic somnolence with lithium. Archives of Neurology1977; 27: 143.