Intravenous diazepam has been shown to produce both a fall in forearm blood flow and coincidental diminution in subjective anxiety, as compared with the resting state and after injection of intravenous saline.
References
1.
BlairD. A.GloverW. E.GreenfieldA. D. M.RoddieI. C. (1959). Excitation of cholinergic vasodilator nerves to human skeletal muscles during emotional stress. J. Physiol. (London)148: 633.
2.
ChaiC. Y.WangS. C. (1966). Cardiovascular actions of diazepam in the cat. J. Pharmacol. Exp. Ther., 154: 271.
3.
ClemensT. L.SelesnickS. T. (1967). Psychological method for evaluating medication by repeated exposure to a stressor film. Dis. Nerv. Syst.28: 98.
HiltonS. M. (1963). Lecture on the hypothalamic control of the cardio-vascular responses in fear and rage, delivered at the London School of Hygiene and Tropical Medicine, November 14th, 1963. Quoted by Kelly, D. H. W. Brit. J. Psychiat.112: 789.
6.
KellyD. H. W. (1966). Measurement of anxiety by forearm blood flow. Brit. J. Psychiat.112: 789.
7.
KellyD. H. W. (1967). The technique of forearm plethysmography for assessing anxiety. J. Psychosom. Res., 10: 373.
8.
KellyD. H. W.WalterC. J. S. (1968). The relationship between clinical diagnosis and anxiety assessed by forearm blood flow and other measurements. Brit. J. Psychiat.114: 611–626.
9.
RosenbergC. M.ButtsworthF. J.Anxiety in Alcoholics. Quart. J. Stud. Ale. (in press).
