Experimental investigators have discussed the therapeutic potential of ephedrine as a thermogenic agent in the treatment of obese individuals. Because research into thermogenesis and the role of sympathetic nervous system stimulation in weight control primarily has emphasized pharmacological interventions, the authors suggest that cognitive restructuring and covert conditioning procedures could be valuable psychotherapeutic additions to a pharmacologically derived weight-loss regimen. Furthermore, it is concluded that additional clinical research is necessary to determine the efficacy of integrating ephedrine therapy and cognitive-behavioral psychotherapeutic procedures as adjuncts to a multidimensional program for treating obesity.
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References
1.
AstrupA.BulowJ.ChristensenN. J.MadsenJ. (1984) Ephedrine-induced thermogenesis in man: No role for interscapular brown adipose tissue. Clinical Science, 66, 179–186.
2.
AstrupA.LundsgaardC.MadsenJ.ChristensenN. J. (1985) Enhanced thermogenic responsiveness during chronic ephedrine treatment in man. American Journal of Clinical Nutrition, 42, 83–94.
3.
BeckA. T.EmeryG. (1985) Anxiety disorders and phobias: A cognitive perspective. New York: Guilford.
4.
BeckA. T.RushA. J.ShawB. F.EmeryG. (1979) Cognitive therapy of depression. New York: Guilford.
5.
BlockJ. (1980) Effects of rational-emotive therapy on overweight adults. Psychotherapy: Theory, Research and Practice, 17, 277–280.
6.
BowinR. (1983) An empirical study of rational-emotive therapy in management of stress. Psychological Reports, 53, 196–198.
7.
BrownellK. D. (1982) Obesity: Understanding and treating a serious, prevalent, and refractory disorder. Journal of Consulting and Clinical Psychology, 50, 820–840.
8.
BrownellK. D.ForeytJ. P. (1985) Obesity. In BarlowD. H. (Ed.), Clinical handbook of psychological disorders. New York: Guilford. Pp. 299–343.
9.
BrownellK. D.WaddenT. A. (1986) Behavior therapy for obesity: Modern approaches and better results. In BrownellK. D.ForeytJ. P. (Eds.), Handbook of eating disorders: Physiology, psychology, and treatment of obesity, anorexia, and bulimia. New York: Basic Books. Pp. 180–197.
10.
BukowieckiL.FolleaN.ParadisA.ColletA. (1980) Stereospecific stimulation of brown adipocyte respiration by catecholamines via beta–1-adrenoreceptors. American Journal of Physiology, 238, E552–E563.
11.
BukowieckiL.FolleaN.VallieresJ.LeblancJ. (1978) Beta receptors in brown adipose tissue: Characterization and alterations during acclimation of rats to cold. European Journal of Biochemistry, 92, 189–196.
12.
BukowieckiL.JahjahL.FolleaN. (1982) Ephedrine, a potential slimming drug, directly stimulates thermogenesis in brown adipocytes via beta-adrenoreceptors. International Journal of Obesity, 6, 343–350.
13.
BukowieckiL. J.LupienJ.FolleaN.JahjahL. (1983) Effects of sucrose, caffeine, and cola beverages on obesity, cold resistance, and adipose tissue cellularity. American Journal of Physiology, 244, R500–R507.
14.
BurnsD. (1980) Feeling good: The new mood therapy. New York: Morrow.
15.
CautelaJ. R. (1985) Covert conditioning. In BellackA. S.HersenM. (Eds.), Dictionary of behavior therapy techniques. New York: Pergamon. Pp. 86–91.
16.
CautelaJ. R.BennettA. K. (1981) Covert conditioning. In CorsiniR. (Ed.), Handbook of innovative psychotherapies. New York: Wiley. Pp. 189–204.
17.
CummingsC.GordonR.MarlattG. A. (1980) Relapse: Prevention and prediction. In MillerW. R. (Ed.), The addictive behaviors. New York: Pergamon. Pp. 291–321.
18.
DepocasF.BehrensW. A.FosterD. O. (1978) Noradrenaline-induced calorigenesis in warm- and cold-acclimated rats. The interrelation of dose of noradrenaline, its concentration in arterial plasma and calorigenic response. Canadian Journal of Physiology and Pharmacology, 56, 168–174.
19.
DullooA. G.MillerD. S. (1984) Thermogenic drugs for the treatment of obesity: Sympathetic stimulants in animal models. British Journal of Nutrition, 52, 179–196.
20.
EllisA.DrydenW. (1987) The practice of rational-emotive therapy (RET). New York: Springer.
21.
EvansE.MillerD. S. (1977) The effect of ephedrine on the oxygen consumption of fed and fasted subjects. Proceedings of the Nutrition Society, 36, 136A.
22.
ForeytJ. P. (1987) The addictive disorders. In WilsonG. T.FranksC. M.KendallP. C.ForeytJ. P. (Eds.), Annual review of behavior therapy: Theory and practice. Vol. 11. New York: Guilford. Pp. 187–233.
23.
FosterD. O.FrydmanM. L. (1978) Nonshivering thermogenesis in the rat: II. Measurements of blood flow with microspheres point to brown adipose tissue as the dominant site of calorigenesis induced by noradrenaline. Canadian Journal of Physiology and Pharmacology, 56, 110–122.
24.
KrieshokS. I.KarpowitzD. H. (1988) A review of selected literature on obesity and guidelines for treatment. Journal of Counseling and Development, 66, 326–330.
25.
LeBlancJ.DussaultJ.LupienD.RichardD. (1982) Effect of diet and exercise on norepinephrine-induced thermogenesis in male and female rats. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology, 52, 556–561.
26.
Malchow-MollerA.LarsenS.HeyH.StockholmK. H.JuhlE.QuaadeF. (1981) Ephedrine as an anorectic: The story of the “Elsinore pill.”International Journal of Obesity, 5, 183–187.
27.
MarcusM. D. (1985) Obesity. In HersenM.LastC. G. (Eds.), Behavior therapy casebook. New York: Springer. Pp. 144–157.
28.
MarshallW. L. (1985) Exposure. In BellackA. S.HersenM. (Eds.), Dictionary of behavior therapy techniques. New York: Pergamon. Pp. 121–124.
29.
MorganJ. B.YorkD. A.WasilewskaA.PortmanJ. (1982) A study of the thermic responses to a meal and to a sympathomimetic drug (ephedrine) in relation to energy balance in man. British Journal of Nutrition, 47, 21–32.
30.
RothwellN. J.StockM. J. (1979) A role for brown adipose tissue in diet-induced thermogenesis. Nature (London), 281, 31–35.
31.
RothwellN. J.StockM. J.WyllieM. G. (1981) Sympathetic mechanisms in diet-induced thermogenesis: Modification by ciclazindol and anorectic drugs. British Journal of Pharmacology, 74, 539–546.
32.
WarrenR.McLellarnR.PonzohaC. (1987) Rational-emotive therapy vs. general cognitive-behavior therapy in the treatment of low self-esteem and related emotional disturbances. Cognitive Therapy and Research, 12, 21–38.
33.
WeinerN. (1985) Norepinephrine, epinephrine, and the sympathomimetic amines. In GilmanA. G.GoodmanL. S.RallT. W.MuradF. (Eds.), Goodman and Gilman's ‘The pharmacological basis of therapeutics.' (7th ed.) New York: Macmillan. Pp. 145–180.
34.
WeishmaarM.BeckA. T. (1986) Cognitive therapy. In DrydenW.GoldenW. (Eds.), Cognitive-behavioural approaches to psychotherapy. London: Harper & Row. Pp. 61–91.
35.
WellmanP. J. (1984) Influence of dl-phenylpropanolamine on brown adipose tissue thermogenesis in the adult rat. Physiological Psychology, 12, 307–310.
36.
WellmanP. J.MarmonM. M. (1985) Synergism between caffeine and dl-phenylpropanolamine on brown adipose tissue thermogenesis in the adult rat. Pharmacology, Biochemistry and Behavior, 22, 781–785.
37.
WellmanP. J.SellersT. L. (1986) Weight loss induced by chronic phenylpropanolamine: Anorexia and brown adipose tissue thermogenesis. Pharmacology, Biochemistry and Behavior, 24, 605–611.
