A set of monozygotic female quadruplets developed schizophrenia at age 26 and were treated at the National Institute of Mental Health for several years. Using graphic material of these unusual subjects, this study demonstrates how handwriting, statistically in graph forms, expresses the developmental stages before (at age 16), during the acute phase of the disease (age 26 to 28) and 25 yr. later (age 51) when they functioned outside a hospital setting in various degrees of competency.
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