Rats (24 male, 24 female) were tested under methamphetamine or saline in a six-choice-point multiple-T maze. On Trial 1 the rats were exposed to a homogeneous black or white maze. Between daily Trials 1 and 2 the maze was: (a) left unchanged, (b) the culs were changed from Black (B) to White (W) or W to B, or (c) the path was changed from B to W, or W to B. Methamphetamine-treated rats made fewer approach responses to change when the change occurred in the culs and spent less time running from one end of the maze to the other. Methamphetamine reduces the invitational properties normally associated with change or novelty.
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