In the present work, a dose-response relationship for bufotenin in the rat trained to bar-press for water reinforcement has been established. Our data illustrate that pretreatment of the rat with chlorpromazine potentiates the behavioral effects of bufotenin, while pretreatment with a tricyclic antidepressant drug does not alter the dose-response relationship for bufotenin. If a similar interacting effect between chlorpromazine and bufotenin were to be demonstrated for the human, it would suggest evidence that bufotenin is not an endogenous psychotogen involved as an etiologic factor in schizophrenia. Such a parallel relationship is suggested by earlier work of Turner and Merlis (1959).
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