An experiment was performed to study the effects of a schizophrenic mimicking compound (B 3,4 Dimethoxyphenel-ethalamine) on the activity of rats. Baseline activity was derived for two groups of 10 rats each during four 3-min. trials in an open-field test. 2.8 g/kg weight of the drug or placebo was then injected into the rats. They were run at 50-min. intervals. The activity level of the post-injection trials was compared with the mean baseline activity within and between the groups. The activity level of the compound-injected group decreased significantly as predicted.
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