Abstract
An experimental method for testing the behavioral performance in primates (monkeys) has been devised and data resemble those states seen early in the clinical uremic syndrome. Previous work demonstrating alterations in behavioral performance in both reversible and irreversible uremic states were discussed. The behavioral deficits following experimental uremic states were not found to be invariants of urea nitrogen levels. Other causative compounds or agents are suspected. The findings from two monkeys following the injection of purified material from a uremic human resembled the alterations observed during continuous urine reinfusion. Two, and possibly four, of 10 samples from a uremic human affected the behavioral performance of two monkeys. The method merits further study.
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