Two groups of mice were given acquisition trials followed by reversal training in a water maze. Experimental Ss were convulsed with a single audiogenic seizure immediately following the last reversal trial. 50% of the latter Ss showed retention of the initial response, but retrograde amnesia for the reversed maze habit. Control Ss all showed retention of the reversed response. The data tend to support the conclusion that audiogenic seizure is partially effective in disrupting the consolidation of the memory trace.
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