Objective and subjective reactions to drug and placebo treatments were studied in 15 healthy Ss under three conditions: (1) 200 mg. Pentobarbitone introduced as a depressant drug, (2) 200 mg. Pentobarbitone introduced as a drug the actions of which were not known to E, and (3) a placebo introduced as a depressant drug. Mean time-response curves showed that pulse rate, objective and subjective reaction speed, and subjective wakefulness were decreased by all treatments. The greatest effects were produced by Pentobarbitone introduced as a depressant while Pentobarbitone alone was, on the whole, less effective than the placebo introduced as a depressant drug.
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