12 nondemented patients with Parkinson's disease (M age = 67.3) and 12 normal control participants were administered an object-based attention task that enabled examination of both negative and positive priming. Unlike previous studies in which spatial-based attention tasks were used, results of the present study indicated that the patients displayed negative and positive priming not different from those shown by controls. These results suggest that certain object-based attentional processes may not be impaired in patients with Parkinson's disease.
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References
1.
BaizerJ. S.DesimoneR.UngerleiderL. G. (1993) Comparison of subcortical connections of inferior temporal and posterior parietal cortex in monkeys. Visual Neuroscience, 10, 59–72.
2.
BehrmannM.TipperS. P. (1994) Object-based visual attention: Evidence from unilateral neglect. In UmiltaC.MoscovitchM. (Eds.), Attention and performance: 15. Conscious and nonconscious processing and cognitive functioning.Cambridge, MA: MIT Press. Pp. 351–375.
BrownR. G.MarsdenC. D. (1990) Cognitive function in Parkinson's disease: From description to theory. Trends in Neuroscience, 13, 21–29.
5.
BrownR. G.MarsdenC. D. (1991) Dual task performance and processing resources in normal subjects and patients with Parkinson's disease. Brain, 114, 215–231.
6.
BurtonE. J.McKeithI. G.BurnD. J.WilliamsE. D.O'BrienJ. T. (2004) Cerebral atrophy in Parkinson's disease with and without dementia: A comparison with Alzheimer's disease, dementia with Lewy bodies, and controls. Brain, 127, 791–800.
7.
CastielloU.BonfiglioliC.PeppardR. F. (2000) Dopaminergic effects on the implicit processing of distractor objects in Parkinson's disease. Experimental Brain Research, 135, 251–258.
8.
CohenS. M. (1972) Electrical stimulation of cortical caudate pairs during delayed successive visual discrimination in monkeys. Acta Neurobiological Experiments, 32, 211–233.
9.
CoolsR.BarkerR. A.SahakianB. J.RobbinsT. W. (2001) Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands. Cerebral Cortex, 11, 1136–1143.
10.
CoolsR.BarkerR. A.SahakianB. J.RobbinsT. W. (2003) L-dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's disease. Neuropsychologia, 41, 1431–1441.
11.
CostaA.PeppeA.Dell'AgnelloG.CarlesimoG. A.MurriL.BonuccelliU.CaltagironeC. (2003) Dopaminergic modulation of visual-spatial working memory in Parkinson's disease. Dementia and Geriatric Cognitive Disorders, 15, 55–66.
12.
CourtneyS. M.UngerleiderL. G.KeilK.HaxbyJ. V. (1996) Object and spatial visual working memory activate separate neural systems in human cortex. Cerebral Cortex, 6, 39–49.
13.
CummingsJ. L. (1993) Frontal-subcortical circuits and human behavior. Archives of Neurology, 50, 873–880.
14.
Dalrymple-AlfordJ. C.KaldersA. S.JonesR. D.WatsonR. W. (1994) A central executive deficit in patients with Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 57, 360–367.
15.
DivacI.RosvoldH. E.SzwarcbartM. K. (1967) Behavioral effects of selective ablation of the caudate nucleus. Journal of Comparative Physiology and Psychology, 63, 184–190.
16.
DoubleK. L.HallidayG. M.McRitchieD. A.ReidW. G.HelyM. A.MorrisJ. G. (1996) Regional brain atrophy in idiopathic Parkinson's disease and diffuse Lewy body disease. Dementia, 7, 304–313.
17.
DuncanJ. (1984) Selective attention and the organization of visual information. Journal of Experimental Psychology: General, 113, 501–517.
18.
FiloteoJ. V.DelisD. C.SalmonD. P.DemaduraT. L.RomanM. J.ShultsC. W. (1997) An examination of the nature of attentional deficits in patients with Parkinson's disease: Evidence from a spatial orienting task. Journal of the International Neuropsychological Society, 3, 337–347.
19.
FiloteoJ. V.FriedrichF. J.RillingL. M.DavisJ. D.StrickerJ. L.PrenovitzM. (2003) Semantic and cross-case identity priming in patients with Parkinson's disease. Journal of Clinical and Experimental Neuropsychology, 25, 441–456.
20.
FiloteoJ. V.MaddoxT. W. (1999) Quantitative modeling of visual attention processes in patients with Parkinson's disease: Effects of stimulus integrality on selective attention and dimensional integration. Neuropsychology, 13, 206–222.
21.
FiloteoJ. V.RillingL. M.StrayerD. L. (2002) Negative priming in patients with Parkinson's disease: Evidence for a role of the striatum in inhibitory attentional processes. Neuropsychology, 16, 230–241.
22.
FournetN.MoreaudO.RoulinJ. L.NaegeleB.PellatJ. (2000) Working memory functioning in medicated Parkinson's disease patients and the effect of withdrawal of dopaminergic medication. Neuropsychology, 14, 247–253.
23.
HayesA. E.DavidsonM. C.KeeleS. W.RafalR. D. (1998) Toward a functional analysis of the basal ganglia. Journal of Cognitive Neuroscience, 10, 178–198.
24.
HenikA.SinghJ.BeckleyD. J.RafalR. D. (1993) Disinhibition of automatic word reading in Parkinson's disease. Cortex, 29, 589–599.
25.
HoehnM. M.YahrM. D. (1967) Parkinsonism: Onset, progression and mortality. Neurology, 17, 427–442.
26.
HoughtonG.TipperS. P. (1994) A model of inhibitory mechanisms in selective attention. In DagenbachD.CarrT. H. (Eds.), Inhibitory processes in attention, memory, and language.San Diego, CA: Academic Press. Pp. 53–112.
27.
HsiehS.LeeC-Y.HwangW-J.TsaiJ-J. (1997) Object-b ased and location-based shifting of attention in Parkinson's disease. Perceptual and Motor Skills, 85, 1315–1325.
28.
IversonS. D. (1979) Behavior after neostriatal lesions in animals. In DivacI.ObergR. G. E. (Eds.), The neostriatum.Oxford: Pergamon. Pp. 192–210.
29.
KaasinenV.AaltoS.NagrenK.HietalaJ.SonninenP.RinneJ. O. (2003) Extrastriate dopamine D2 receptors in Parkinson's disease: A longitudinal study. Journal of Neural Transmission, 110, 591–601.
30.
KishS. J.ShannakK.HornykiewiczO. (1988) Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease: Pathophysiologic and clinical implications. The New England Journal of Medicine, 318, 876–880.
31.
KramerA. F.StrayerD. L. (2001) Influence of stimulus repetition on negative priming. Psychology and Aging, 16, 580–587.
32.
LangeK. W.RobbinsT. W.MarsdenC. D.JamesM.OwenA. M.PaulG. M. (1992) L-dopa withdrawal in Parkinson's disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction. Psychopharmacology, 107, 294–404.
33.
LeeS. S.WildK.HollnagelC.GrafmanJ. (1999) Selective visual attention in patients with frontal lobe lesions or Parkinson's disease. Neuropsychologia, 37, 595–604.
34.
LevyR.FriedmanH. R.DavachiL.Goldman-RakicP. S. (1997) Differential activation of the caudate nucleus in primates performing spatial and nonspatial working memory tasks. Journal of Neuroscience, 17, 3870–3882.
35.
LiebK.BruckerS.BachM.ElsT.LuckingC. H.GreenleeM. W. (1999) Impairment in preattentive visual processing in patients with Parkinson's disease. Brain, 122, 303–313.
36.
MaddoxW. T.FiloteoJ. V.DelisD. C.SalmonD. P. (1996) Visual selective attention deficits in patients with Parkinson's disease: A quantitative model-based approach. Neuropsychology, 10, 197–218.
McDowellS. A.HarrisJ. (1997) Irrelevant peripheral visual stimuli impair manual reaction times in Parkinson's disease. Vision Research, 37, 3549–3558.
39.
NeillW. T. (1977) Inhibitory and facilitatory processes in selective attention. Journal of Experimental Psychology: Human Perception and Performance, 3, 444–450.
40.
OwenA. M.RobertsA. C.HodgesJ. R.SummersB. A.PolkeyC. E.RobbinsT. W. (1993) Contrasting mechanisms of impaired attentional set-shifting in patients with frontal lobe damage or Parkinson's disease. Brain, 116, 1159–1175.
41.
PostleB. R.D'EspositoM. D. (1999) Dissociation of human caudate nucleus activity in spatial and nonspatial working memory: An event related fMRI study. Cognitive Brain Research, 8, 107–115.
42.
PraamstraP.PlatF. M. (2001) Failed suppression of direct visuomotor activation in Parkinson's disease. Journal of Cognitive Neuroscience, 13, 31–43.
43.
RafalR. D.PosnerM. I.WalkerJ. A.FriedrichF. J. (1984) Cognition and the basal ganglia: Separating mental and motor components of performance in Parkinson's disease. Brain, 107, 1083–1094.
44.
RothermundK.WenturaD.De HouwerJ. (2005) Retrieval of incidental stimulus-response associations as a source of negative priming. Journal of Experimental Psychology, 31, 482–495.
45.
SchollB. J. (2001) Objects and attention: The state of the art. Cognition, 80, 1–46.
46.
SharpeM. H. (1990) Patients with early Parkinson's disease are not impaired on spatial orienting of attention. Cortex, 26, 515–524.
47.
SohnM.UrsuS.AndersonJ. R.StengerV. A.CarterC. S. (2000) The role of prefrontal cortex and posterior parietal cortex in task switching. Proceedings of the National Academy of Sciences, 97, 13448–13453.
48.
TipperS. P. (1985) The negative priming effect: Inhibitory priming by ignored objects. The Quarterly Journal of Experimental Psychology, A, 37, 571–590.
49.
TipperS. P.MillikenB. (1996) Distinguishing between inhibition-based and episodic retrieval-based accounts of negative priming. In KramerA. F.ColesM. G. H.LoganG. D. (Eds.), Converging operations in the study of visual selective attention.Washington, DC: American Psychological Association. Pp. 337–364.
50.
UngerleiderL.MishkinM. (1982) Two cortical visual systems. In IngleD. J.GoodaleM. A.MansfieldR. J. W. (Eds.), Analysis of visual behavior.Cambridge, MA: MIT Press. Pp. 549–586.
51.
WilsonF. A.O'ScalhaideS. P.Goldman-RakicP. S. (1993) Dissociation of object and spatial processing domains in primate prefrontal cortex. Science, 260, 1955–1958.
52.
WrightM. J.BurnsR. J.GeffenG. M.GeffenL. B. (1990) Covert orientation of visual attention in Parkinson's disease: An impairment in the maintenance of attention. Neuropsychologia, 28, 151–159.
53.
WylieS. A.StoutJ. C. (2002) Enhanced negative priming in Parkinson's disease. Neuropsychology, 16, 242–250.
54.
YamaguchiS.KobayashiS. (1998) Contributions of the dopaminergic system to voluntary and automatic orienting of visuospatial attention. Journal of Neuroscience, 18, 1869–1878.
55.
YantisS.SerencesJ. T. (2003) Cortical mechanisms of space-based and object-based attentional control. Current Opinions in Neurobiology, 13, 187–193.
56.
YesavageJ. A.BrinkT. L.RoseT. L.LumO.HuangV.AdeyM.LeirerV. O. (1983) Development and validation of a geriatric depression screening scale: A preliminary report. Journal of Psychiatric Research, 17, 37–49.
57.
YeterianE. H.PandyaD. N. (1991) Prefrontal connections in relation to cortical architectonic organization in rhesus monkeys. The Journal of Comparative Neurology, 312, 43–67.
58.
YeterianE. H.PandyaD. N. (1995) Corticostriatal connections of extrastriate visual areas in rhesus monkeys. The Journal of Comparative Neurology, 352, 436–457.
