Antiirritants are used in cosmetic products to prevent or to treat skin irritations that arise during daily life. Data were published earlier on the efficacy of the best-known humectant, glycerol, in reducing irritation.
Objective:
The aim of the present study was to examine the effects of different polyols (including glycerol, xylitol, and mannitol) and the amino acids taurine and glycine on sodium lauryl sulfate (SLS)-induced skin irritation.
Methods:
Healthy adult volunteers were patch-tested with 0.1% SLS in the presence or absence of one or another polyol or amino acid. Skin reactions were evaluated via measurements of transepidermal water loss (TEWL).
Results:
Glycerol and xylitol significantly suppressed the SLS-induced increase in TEWL, whereas mannitol had no effect on the SLS-induced skin irritation. Taurine also inhibited the SLS-induced increase in TEWL, but glycine was not effective in reducing the SLS-induced irritative response.
Conclusion:
Similar to the action of the well-known antiirritant glycerol, SLS-induced skin irritation is suppressed by xylitol and taurine. These results suggest that these agents might also be effective in preventing irritative dermatitis.
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References
1.
GloorM.How do dermatologic vehicles influence the horny layer?. Skin Pharmacol Physiol, 2004; 17:267-73, doi:10.1159/000081111.
2.
AndersenF, HedegaardK, PetersenTK, et al.Comparison of the effect of glycerol and triamcinolone acetonide on cumulative skin irritation in a randomized trial. J Am Acad Dermatol, 2007; 56:228-35, doi:10.1016/j.jaad.2006.08.063.
FluhrJW, DarlenskiR, SurberC. Glycerol and the skin: a holistic approach to its origin and functions. Br J Dermatol, 2008; 159:23-34, doi:10.1111/j.1365-2133.2008.08643.x.
5.
WarskulatU, ReinenA, Grether-BeckS, et al.The osmolyte strategy of normal human keratinocytes in maintaining cell homeostasis. J Invest Dermatol, 2004; 123:516-21, doi:10.1111/j.0022-202X.2004.23313.x.
6.
AnderheggenB, JassoyC, Waldmann-LaueM, et al.Taurine improves epidermal barrier properties stressed by surfactants—a role for osmolytes in barrier homeostasis. J Cosmet Sci, 2006; 57: 1-10.
7.
MarrubiniG, CaccialanzaG, MassoliniG. Determination of glycine and threonine in topical dermatological preparations. J Pharm Biomed Anal, 2008; 47:716-22, doi:10.1016/j.jpba.2008.02.024.
8.
AgnerT, SerupJ. Skin reactions to irritants assessed by non-invasive bioengineering methods. Contact Dermatitis, 1989; 20:352-9, doi:10.1111/j.1600-0536.1989.tb03172.x.
9.
LeeCH, MaibachHI. The sodium lauryl sulfate model: an overview. Contact Dermatitis, 1995; 33:1-7, doi:10.1111/j.1600-0536.1995.tb00438.x.
10.
AgnerT, SerupJ. Sodium lauryl sulfate for irritant patch testing—a dose-response study using bioengineering methods for determination of skin irritation. J Invest Dermatol, 1990; 95:543-7, doi:10.1111/1523-1747.ep12504896.
11.
TupkerRA, WillisC, BerardescaE, et al.Guidelines on sodium lauryl sulfate (SLS) exposure tests. A report from the Standardization Group of the European Society of Contact Dermatitis. Contact Dermatitis, 1997; 37:53-69, doi:10.1111/j.1600-0536.1997.tb00041.x.
12.
TupkerRA.Testing ESCD application and reading standards. In: SerupJ, JemecGBE, GroveGL, editors. Handbook of non-invasive methods and the skin. Boca Raton: CRC Press; 2005. p. 943-55.
13.
AgnerT, HeldE, WestW, GrayJ. Evaluation of an experimental patch test model for the detection of irritant skin reactions to moisturisers. Skin Res Technol, 2000; 6:250-4, doi:10.1034/j.1600-0846.2000.006004250.x.
14.
RosadoC, RodriguesLM. Assessment of dry skin using dynamic methods. J Appl Cosmetol, 2006; 24:149-58.
15.
PinnagodaJ, TupkerRA, AgnerT, SerupJ. Guidelines for transepidermal water loss (TEWL) measurement. A report from the Standardization Group of the European Society of Contact Dermatitis. Contact Dermatitis, 1990; 22:164-78, doi:10.1111/j.1600-0536.1990.tb01553.x.
16.
RogiersV.EEMCO guidance for the assessment of transepidermal water loss in cosmetic sciences. Skin Pharmacol Appl Skin Physiol, 2001; 14:117-28.
17.
AndersenF, HedegaardK, PetersenTK, et al.Antiirritants I: doseresponse in acute irritation. Contact Dermatitis, 2006; 55:148-54, doi:10.1111/j.1600-0536.2006.00752.x.
18.
KeményL, KoreckA, KisK, et al.Endogenous phospholipid metabolite containing topical product inhibits ultraviolet lightinduced inflammation and DNA damage in human skin. Skin Pharmacol Physiol, 2007; 20:155-61, doi:10.1159/000098702.
19.
SeidenariS, GiustiF, PellacaniG.Instrumental evaluation of occluded patch test reaction. In: SerupJ, JemecGBE, GroveGL, editors. Handbook of non-invasive methods and the skin. Boca Raton: CRC Press; 2005. p. 973-9.
20.
LevequeJL, de RigalJ, Saint-LegerD, BillyD. How does sodium lauryl sulfate alter the skin barrier function in man? A multiparametric approach. Skin Pharmacol, 1993; 6:111-5, doi:10.1159/000211095.
21.
GhoshS, BlankschteinD. The role of sodium dodecyl sulfate (SDS) micelles in inducing skin barrier perturbation in the presence of glycerol. J Cosmet Sci, 2007; 58:109-33.
22.
FluhrJW, GloorM, LehmannL, et al.Glycerol accelerates recovery of barrier function in vivo. Acta Derm Venereol, 1999; 79:418-21, doi:10.1080/000155599750009825.
23.
SimionFA, AbrutynES, DraelosZD. Ability of moisturizers to reduce dry skin and irritation and to prevent their return. J Cosmet Sci, 2005; 56:427-44.
24.
RawlingsA, HardingC, WatkinsonA, et al.The effect of glycerol and humidity on desmosome degradation in stratum corneum. Arch Dermatol Res, 1995; 287:457-64, doi:10.1007/BF00373429.
25.
SavicaS, TamburicS, SavicM, et al.Vehicle-controlled effect of urea on normal and SLS-irritated skin. Int J Pharm, 2004; 271:269-80, doi:10.1016/j.ijpharm.2003.11.033.
26.
CohenS, MarcusY, MigronY, et al.Water sorption, binding and solubility of polyols. J Chem Soc Faraday Trans, 1993; 89:3271-5, doi:10.1039/ft9938903271.
