The search for the ideal bone substitute began hundreds of years ago, and continues today. While numerous choices have been proposed and tested, with varying degrees of success, there remain many challenges related to the use of bone substitutes in craniofacial reconstruction. This paper presents a review of the history of bone substitute research, a discussion of currently popular materials, and elucidation of the challenges to be faced as we approach the new millennium.
AlbrektssonT.. In vivo studies of bone grafts.Orthop Scand.1980; 51: 9–17.
2.
BucholzR.W.CarltonA.HolmesR.E.. Hydroxyapatite and tricalcium phosphate bone graft substitutes.Orthop Clin North Am.1987; 18: 323–334.
3.
BursteinF.D.CanalisR.F.. Studies on the osteogenic potential of vascularized periosteum: behavior of periosteal flaps transferred onto soft tissue.Otolaryngol Head Neck Surg.1985; 93: 731–735.
4.
BursteinS.CohenS.HudginsR.BoydstonW.. The use of porous granular hydroxyapatite in secondary orbitocranial reconstruction.Plast Reconstr Surg.1997; 100: 869–874.
5.
CookS.D.WolfeM.W.SalkedS.L.. Recombinant human osteogenic protein-1 (rh OP-1) heals segmental defects in nonhuman primates.J Bone Joint Surg.1995; 77A: 734–755.
6.
CostantinoP.D.FriedmanC.D.JonesK.ChowL.C.PelzerH.J.SissonG.A.. Hydroxyapatite cement I: basic chemistry and histological properties.Arch Otolaryngol Head Neck Surg.1991; 117: 379–384.
7.
CostantinoP.D.FriedmanC.D.LaneA.. Synthetic biomaterials in facial plastic and reconstructive surgery.Facial Plast Surg.1993; 9: 1–15.
8.
DamienC.J.ParsonsJ.R.. Bone graft and bone graft substitutes: a review of current technology and applications.J Appl Biomater.1991; 2: 187–208.
9.
DucheyeneP.. Bioactive ceramics.J Bone Joint Surg Br.1994; 76: 861–862. Editorial.
10.
EdbergE.. Some experiences in filling osseous cavities with plaster.Acta Chir Scand.1930; 67: 313–319.
11.
FrameJ.W.. A composite of porous calcium sulphate dihydrate and cyanoacrylate as a substitute for autogenous bone.J Oral Surg.1980; 38: 251–256.
12.
FreidlanderG.E.. Current concepts review: bone grafts.J Bone Joint Surg.1987; 69A: 786.
13.
GlowackiJ.AltobellD.MullikenJ.B.. Fate of mineralized and demineralized osseous implants in cranial defects.Calcif Tissue Int.1981; 33: 71–76.
14.
GoldbergV.M.StevensonS.. Natural history of autografts and allografts.Clin Orthop.1987; 225: 7–16.
15.
IshikawaK.TakugiS.ChowL.. Properties and mechanisms of fast-setting calcium phosphate cements.J Mater Sci Mater Med.1925; 6: 528–533.
16.
KenleyR.MardenL.TurekT.JinL.RonE.HollingerJ.O.. Osseous regeneration in the rat calvarium using novel delivery systems for recombinant human bone morphogenic protein-2.J Biomed Mater Res.1994; 28: 1130–1147.
17.
KenleyR.YimK.AbramsJ.RonE.TurekT.MardenL.J.HollingerJ.O.. Biotechnology and bone graft substitutes.Pharmacol Res.1993; 10: 1393–1401.
18.
KleinC.de GrootK.DriesenA.vander LubbeH.B.. A comparative study of different [beta]-whitlockite ceramics in rabbit cortical bone with regard to their biodegradation behavior.Biomaterials1986; 7: 144–146.
