In this case report, we present an unusual combination of three congenital malformations: median cleft of the lower lip, lip pits, and unilateral cleft of the lip and palate without familial occurrence.
Conclusions
From an etiological point of view, this combination of malformations could have happened during the late embryogenic period. Why this combination is uncommon is not known.
BurdickA.B., BixlerD., PuckettC.H.L.. Genetic analysis in families with van der Woude syndrome.J Craniofac Genet Dev Biol1985; 5: 181–208.
2.
CervenkaJ., GorlinR.J., AndersonV.E.. The syndrome of pits of the lower lip and cleft lip and/or palate. Genetic considerations.Am J Hum Genet1967; 19: 416–432.
3.
FujinoH., KyoshoinY., KatsukiT.. Median cleft of the lower lip, mandible, and tongue with midline cervical cord: a case report.Cleft Palate J1970; 7: 679–684.
4.
GrabbW.C., RosensteinS.W., BzochK.R.. Cleft Lip and Palate. Surgery, Dental and Speech Aspects.Boston: Little, Brown and Co;1971.
5.
MarcadeE., BabutJ.M., PailheretJ.P., AllouisM.. Fente mediane de la levre inferieure.Ann Chir Plast1981; 26: 148–150.
6.
MillardDRJr., LehmanJAJr., DeaneM., GarstW.P.. Median cleft of the lower lip and mandible; a case report.Br J Plast Surg1971; 24: 391–395.
7.
MonroeC.W.. Midline cleft of the lower lip, mandible and tongue with flexion contracture of the neck.Plast Reconstr Surg1966; 38: 312–319.
8.
OostromC.A.M., Vermeij-KeersC., GilbertP.M., van der MeulenJ.C.. Median cleft of the lower lip and mandible: case reports, A. New embryogenic hypothesis and subdivision.Plast and Reconstr Surg1996; 97: 313–320.
9.
RantaR.. Incomplete median cleft of the lower lip associated with cleft palate, the Pierre Robin anomaly or hypodontia.Int J Oral Surg1984; 13: 555–558.
10.
RintalaA.E., LahtiA.Y., GyllingU.S.. Congenital sinuses of the lower lip in connection with cleft lip and palate.Cleft Palate J1970; 7: 336–346.
11.
SchinzelA., KlauslerM.. The van der Woude syndrome (dominantly inherited lip pits and clefts).J Med Genet1986; 23: 291–294.
12.
Van der WoudeA.. Fistula labii inferioris congenita and its association with cleft lip and palate.Am J Hum Genet1954; 6: 244–256.
13.
WatanabeY., HakushiI., OtakeH., TomitaK.. Congenital fistula of the lower lip.Oral Surg1951; 4: 709–722.