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Abstract

Objective

This study was conducted to evaluate the relationship between fistulae of the lower lip and cleft lip and/or palate in patients with Van der Woude syndrome.

Methods

The medical records of 11,000 patients with cleft lip and/or palate registered at the Cleft Lip-Palate Research and Rehabilitation Hospital, University of São Paulo, Bauru were reviewed. Of these patients, 133 (1.2%) presented with Van der Woude syndrome.

Results

Of the 133 patients, 88 (66.2%) exhibited full clefts, 22 (16.5%) only cleft lip, and 23 (17.3%) only cleft palate. The lower-lip fistulae observed in these 133 patients were bilateral symmetric in 66 (49.7%), bilateral asymmetric in 42 (31.6%), microform In 19 (14.3%), median in 5 (3.8%), and unilateral in 1 (0.7%).

Conclusion

This population sample appears to exhibit the previously published tendency for bilateral, unilateral, or mixed-type congenital fistulae to be associated with cleft lip with or without cleft palate, while so-called microforms or conic elevations are almost exclusively associated with cleft palate.

Keywords

cleft lip and/or palate congenital fistulas of lower lip Van der Woude syndrome

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References

Baker

B.R.

A family with bilateral congenital pits of the inferior lip.

Oral Surg 1964; 18: 494–497.

Bernaba

J.M.

, Castro

A.C.

, Garrafa

Fistulas congênitas bilaterais do lábio inferior e comissuras labiais - relato de dois casos.

Rev Assoc Paul Cirurg Dent 1973; 27: 17–21.

Bowden

D.E.J.

Bilateral congenital fistulae of the lower lip.

Br J Orthod 1977; 4: 101–102.

Bowers

D.G.

Surgical repair of congenital lower lip sinuses.

Plast Reconstr Surg 1972; 49: 632–636.

Cervenka

, Gorlin

R.J.

, Anderson

V.E.

The syndrome of pits of the lower lip and cleft lip and or palate. Genetic considerations.

Am J Hum Genet 1967; 19: 416–432.

Csiba

Bilateral connate fístual of the lower lip.

Oral Surg 1966; 22: 226–230.

Demarquay

Quelques considérations sur le bec-de-liévre.

Gaz Méd Paris 1845; 13: 52.

Friedhofer

, Bonetti

E.Y.

, Anger

. Sinus labial. Rev Hosp Clin Fac Med Sao Paulo 1984; 39: 93–196.

Gordon

, Davies

, Friedberg

Congenital pits of the lower lip with cleft lip and palate.

S Afr Med J 1969; 43: 1275–1279.

10.

Gorlin

R.J.

, Boogs

W.S.

The genetic aspects of facial abnormalites.

Adv Hum Genet 1977; 8: 235–246.

11.

Gorlin

R.J.

, Cervenka

Syndromes of facial clefting.

Scand J Plast Reconstr Surg 1974; 8: 13–25.

12.

Hall

D.C.

Report of a case of congenital pits of the lower lip associated with cleft palate.

Dent Practit 1964; 14: 227–228.

13.

Koberg

Zur kenntnes der kongenitalen unterlippenfistein: bericht uber 25 eigene falle.

Ost Z Stomatol 1966; 63: 60–74.

14.

Ranta

Correlations of sinus, conical elevation, median depression of the lower lip and types of oral clefts.

Int J Oral Surg 1985; 14: 479–484.

15.

Ranta

, Rintala

A.E.

Correlations between microforms of the Van der Woude syndrome and cleft palate.

Cleft Palate J 1983; 20: 158–161.

16.

Rintala

A.E.

, Lahti

A.Y.

, Gylling

U.S.

Congenital sinuses of the lower lip in connection with cleft lip and palate.

Cleft Palate J 1970; 7: 336–344.

17.

Rintala

A.E.

, Lahti

On so-called median lower lip sinuses: case report, Scand J Plast Reconstr Surg 1973; 7: 78–80.

18.

Rintala

A.E.

, Ranta

Lower lip sinuses: I. Epidemiology, microforms and transverse sulci.

Br J Plast Surg 1981; 34: 26–30.

19.

Sharpe

Congenital lip sinuses: case reports.

Plast Reconstr Surg 1971; 47: 85–86.

20.

Shprintzen

R.J.

, Goldberg

R.B.

, Sidot

E.J.

The penetrance and variable expression of the Van der Woude syndrome. Implications for genetic counseling.

Cleft Palate J 1980; 17: 52–57.

21.

Soricelli

D.A.

, Bell

, Alexander

W.A.

Congenital fistulas of the lower lip.

Oral Surg 1966; 21: 511–516.

22.

Spina

, Psillakis

J.M.

, Lapa

F.S.

, Ferreira

M.C.

Classificação das fissuras lábio-palatais. Sugestão de modificação.

Rev Hosp Clin Fac Med Sao Paulo 1972; 27: 5–6.

23.

Wang

M.K.H.

, Macomber

W.B.

Congenital lip sinuses.

Plast Reconstr Surg 1956; 8: 319–328.

24.

Watanabe

, Hakushi

, Otake

, Tomida

Congenital fistulas of the lower lip: report of five cases with special reference to the etiology.

Oral Surg 1951; 4: 709–722.

25.

Van der Woude

Fistula labii inferioris congenita and its association with cleft lip and palate.

Am J Hum Genet 1954; 6: 244–256.

Relationship between Lower-Lip Fistulae and Cleft Lip and/or Palate in Van der Woude Syndrome

Abstract

Objective

Methods

Results

Conclusion

Keywords

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References