This article reviews neurologic, endocrinologic, and neuropsychological developments that affect our understanding of the adolescent patient. Neuroimaging and neuroradiologic techniques have assisted in identifying brain-behavior relationships and how different neuropsychological patterns result in different ways of thinking. Psychoneuroendocrinologic studies have shown that sex differences in maturation and hormonal effects on behavior need taking into account. At adolescence, the individual with a cleft or craniofacial condition may be at risk for adjustment problems due to earlier developmental events, which may affect language, behavior, and self-esteem.
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