Neutralization of Micrurus distans distans venom by antivenin (Micrurus fulvius) was investigated. Pooled, lyophilized venom from a single specimen was used in all experiments. Micro-Ouchterlony demonstrated multiple precipitin lines between M. distans distans venom and M. fulvius antivenin (AV). The efficacy of M. fulvius AV in neutralizing M. distans distans and M. fulvius venoms in vivo was tested using CD-I mice. All mice received venom plus saline or AV. Survival times were improved in all animals receiving AV. Clinical observation in both groups showed that modes of death were similar. Antivenin (M. fulvius) Wyeth may be useful in the treatment of M. distans distans envenomation.
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