Abstract
A new method to rapidly produce and screen biodegradable polymer- and xerogel-based formulations is described. The approach is based on a high-speed pin printer and imaging with an epi-fluorescence microscope/charge-coupled device detector. By using this approach we can produce and screen over 600 formulations/h and rapidly identify lead formulations and/or compositions that are the most useful for the development of biodegradable devices or (bio)sensors.
Keywords
Get full access to this article
View all access options for this article.
References
1.
Kerns
E. H.
, J. Pharm. Sci. 90 , 1838 (2001 ).
2.
Hertzberg
R. P.
Pope
A. J.
, Curr. Opin. Chem. Biol. 4 , 445 (2000 ).
3.
Hill
D. C.
, Curr. Opin. Drug Discov. Dev. 1 , 92 (1998 ).
4.
Janzen
W. P.
, Lab. Rob. Autom. 8 , 261 (1996 ).
5.
Jaramillo
T. F.
Ivanovskaya
A.
McFarland
E. W.
, J. Comb. Chem. 4 , 17 (2002 ).
6.
Evans
J. R. G.
Edirisinghe
M. J.
Coveney
P. V.
Eames
J.
, J. Eur. Ceram. Soc. 21 , 2291 (2001 ).
7.
Nyden
M. R.
Gilman
J. W.
, Rec. Adv. Flame Rtd. Polym. Mater. 11 , 19 (2000 ).
8.
VanDover
R. B.
Schneemeyer
L. F.
Flemming
R. M.
Huggins
H. A.
, Biotechnol. Bioeng. 61 , 217 (1999 ).
9.
McFarland
E. W.
Weinberg
W. H.
, Trends Biotechnol. 17 , 107 (1999 ).
10.
Jandeleit
B.
Schaefer
D. J.
Powers
T. S.
Turner
H. W.
Weinberg
W. H.
, Angew. Chem., Int. Ed. Engl. 38 , 2494 (1999 ).
11.
Sun
T. X.
, Biotechnol. Bioeng. 61 , 193 (1999 ).
12.
Ottenbrite
R. M.
Huang
S. J.
Park
K.
, Eds., Hydrogels and Biodegradable Polymers for Bioapplications (American Chemical Society , Washington , 1996 ), Vol. 627 .
13.
Hollinger
J. O.
Ed., Biomedical Applications of Synthetic Biodegradable Polymers (CRC , Boca Raton , 1995 ).
14.
Fomin
V. A.
Guzeev
V. V.
, Prog. Rub. Plast. Technol. 17 , 186 (2001 ).
15.
Suggs
L. J.
Mikos
A. G.
, in Physical Properties of Polymers Handbook ,
Mark
J. E.
Ed. (AIP Press , Wodbury , 1996 ).
16.
Brennan
J. D.
, Appl. Spectrosc. 53 , 106A (1999 ).
17.
Ingersoll
C. M.
Bright
F. V.
, CHEMTECH 27 , 26 (1997 ).
18.
MacCraith
B. D.
, Crit. Rev. Opt. Sci. Technol. CR68 , 64 (1997 ).
19.
Martin
P.
, Science (Washington, D.C.) 276 , 75 (1997 ).
20.
Werner
S.
Peters
K. G.
Longaker
M. T.
Fuller-Pace
F.
Banda
M. T.
Williams
L. T.
, Proc. Natl. Acad. Sci. U.S.A. 89 , 6896 (1992 ).
21.
Ulich
T. R.
Yi
E. S.
Longmuir
K.
Yin
S.
Blitz
R.
Morris
C. F.
Housley
R. M.
Pierce
G. F.
, J. Clin. Invest. 93 , 1298 (1994 ).
22.
Hicks
W. L.
Gabalski
E.
Sigurdson
L.
Hall
L.
Holberg
N.
Hard
R.
Kumar
N.
Lwebuga-Mukasa
J.
, Arch. Otol. Head Neck Surg. 125 , 1239 (1999 ).
23.
Hicks
W. L.
Jr.
, Laryngoscope 109 , 1552 (1999 ).
24.
Hicks
W. L.
Jr.
Hall
L. A.
III
Tristram
D. A.
Gardella
J. A.
Jr.
Bright
F. V.
Hard
R.
Sigurdson
L.
, Laryngoscope , paper in press (2002 ).
25.
Sigurdson
L.
Sen
T.
Hall
L.
Rubenfeld
A.
Hard
R.
Gardella
J. A.
Jr.
Bright
F. V.
Lwebuga-Mukasa
J.
Hicks
W. L.
Jr.
, Arch. Otol. Head Neck Surg. , paper in press (2002 ).
26.
Shepherd
P.
Dean
C.
, Eds., Monoclonal Antibodies: A Practical Approach (Oxford University Press , Oxford, U.K. , 2002 ).
27.
Wang
R.
Narang
U.
Prasad
P. N.
Bright
F. V.
, Anal. Chem. 65 , 2671 (1993 ).
28.
Jordan
J. D.
Dunbar
R. A.
Bright
F. V.
, Anal. Chem. 67 , 2436 (1995 ).
29.
Doody
M. A.
Baker
G. A.
Pandey
S.
Bright
F. V.
, Chem. Mater. 12 , 1142 (2000 ).
30.
Dave
B. C.
Dunn
B.
Valentine
J. S.
Zink
J. I.
, Anal. Chem. 66 , 1120A (1994 ).
31.
Ziauddin
J.
Sabatini
D. M.
, Nature (London) 411 , 107 (2001 ).
32.
Schena
M.
Shalon
D.
Davis
R. W.
Brown
P. O.
, Science (Washington, D.C.) 270 , 467 (1995 ).
33.
Cho
E. J.
Bright
F. V.
, Anal. Chem. 73 , 3289 (2001 ).
34.
Cho
E. J.
Bright
F. V.
, Anal. Chem. 74 , 1462 (2002 ).
35.
Cho
E. J.
Bright
F. V.
, Anal. Chim. Acta , paper in press (2002 ).
36.
Cho
E. J.
Tao
Z.
Tang
Y.
Tehan
E. C.
Bright
F. V.
Hicks
W. L.
Jr.
Gardella
J. A.
Jr.
Hard
R.
, J. Biomed. Mater. Res., paper submitted (2002 ).
37.
Lakowicz
J. R.
Ed., Topics in Fluorescence Spectroscopy (Kluwer Academic/Plenum Publishers , New York , 2000 ), Vol. 6 .
38.
Mason
R. L.
Gunst
R. F.
Hess
J. L.
, Statistical Design and Analysis of Experiments: With Applications to Engineering and Science (John Wiley and Sons , New York , 1989 ).
39.
Wolf
R.
Luisi
P. L.
, Biochem. Biophys. Res. Comm. 89 , 209 (1979 ).
40.
Menger
F. M.
Yamada
K.
, J. Am. Chem. Soc. 101 , 6731 (1979 ).
41.
Barbaric
S.
Luisi
P. L.
, J. Am. Chem. Soc. 103 , 4239 (1981 ).
42.
Watnasirichaikul
S.
Davies
N. M.
Rades
T.
Tucker
I. G.
, Pharm. Res. 17 , 684 (2000 ).
43.
O'Hagan
D. T.
, J. Pharm. Pharmacol. 50 , 1 (1998 ).
44.
O'Hagan
D. T.
Ott
G. S.
VanNest
G.
, Mol. Med. Today 3 , 69 (1997 ).
45.
Daubresse
C.
Grandfils
C.
Jerome
R.
Teyssie
P.
, J. Colloid Interface Sci. 168 , 222 (1994 ).
46.
Capozza
R. C.
, U.S. Patent No. 4,322,323 .