Resistance to Linezolid. Are We Surprised? How Hard Should We Look?

Paladino JA . Linezolid: an oxazolidinone antimicrobial agent. Am J Health Syst Pharm 2002; 59: 2413–25.

Pillai SK Sakoulas G Wennersten C Eliopoulos GM Moellering RC Ferraro MJ , Linezolid resistance in Staphylococcus aureus: characterization and stability of resistant phenotype. J Infect Dis 2002; 186: 1603–7.

Tsiodras S Gold HS Sakoulas G Eliopoulos GM Wennersten C Venkataraman L , Linezolid resistance in a clinical isolate of Staphylococcus aureus. Lancet 2002; 358: 207–8.

Prystowsky J Siddiqui F Chosay J Shinabarger DL Millichap J Peterson LR , Resistance to linezolid: characterization of mutations in rRNA and comparison of their occurrences in vancomycin-resistant enterococci. Antimicrob Agents Chemother 2001; 45: 2154–6.

Wilson P Andrews JA Charlesworth R Walesby R Singer M Farrell DJ , Linezolid resistance in clinical isolates of Staphylococcus aureus. J Antimicrob Chemother 2003; 51: 186–8.

Herrero IA Issa NC Patel R . Nosocomial spread of linezolid-resistant vancomycin-resistant Enterococcus faecium. N Engl J Med 2002; 346: 867–9.

Auckland C Teare L Cooke F Kaufmann ME Warner M Jones G , Linezolid-resistant enterococci: report of the first isolates in the United Kingdom. J Antimicrob Chemother 2002; 50: 743–6.

Enne V Howe RA Walsh TR Mutnick AH Jones RN . Initial descriptions of linezolid resistance in S. epidermidis and Streptococcus oralis: report from the SENTRY Antimicrobial Surveillance Program (abstract LB-10). Presented at: The 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, September 27–30, 2002.

Bozdogan G Patel MV Gupte S V De Souza NJ Khorakiwala HF Greenivas K , Characterization of linezolid resistant mutants of Staphylococcus aureus and Streptococcus pneumoniae isolated from mouse in terms of 23S rRNA mutations (abstract 1609). Presented at: The 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, September 27–30, 2002.

Mutnick AH Enne V Jones RN . Linezolid resistance since 2001: SENTRY Antimicrobial Surveillance Program. Ann Pharmacother 2003; 37: 769–74. DOI 10.1345/aph.1C437.

Jones RN Della-Latta P Lee LV Biedenbach DJ . Linezolid-resistant Enterococcus faecium isolated from a patient without prior exposure to an oxazolidinone: report from the SENTRY antimicrobial surveillance network. Diagn Microbiol Infect Dis 2002; 42: 137–9.

Kahlmeter G Brown DFJ . Resistance surveillance studies — comparability of results and quality assurance of methods. J Antimicrob Chemother 2002; 50: 775–7.

Mutnick AH Biedenbach DJ Turnidge JD Jones RN . Spectrum and potency evaluation of a new oxazolidinone, linezolid: report from the SENTRY Antimicrobial Surveillance Program, 1998–2000. Diagn Microbiol Infect Dis 2002; 43: 65–73.

Howe RA Noel AR Bowker KE Bennett PM Walsh TR MacGowan AP . Linezolid resistance in Streptococcus pneumoniae (abstract 1611). Presented at: The 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, September 27–30, 2002.

Gupte SV Sreenivas K Nair S Upadhyay DJ Patel MV Khorakiwala HF , Selection of linezolid resistant mutants of MSSA, MRSA and pneumococci in murine infections (abstract 1610). Presented at: The 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, September 27–30, 2002.

Raad II Hanna HA Arbuckle RA Chaiban G Dvorak T Hachem RY . Susceptibility patterns of vancomycin-resistant enterococci to quinupristin/dalfopristin and linezolid before and after clinical use (abstract 1134). Presented at: The 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, September 27–30, 2002.

Schroeder LK Schreckenberger PC Kelkar S Quinn JP . Nosocomial super-infections due to ampicillin-sensitive, linezolid-resistant Enterococcus faecalis (abstract 1591). Presented at: The 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, September 27–30, 2002.

Jones RN Low DE Pfaller MA . Epidemiologic trends in nosocomial and community-acquired infections due to antibiotic-resistant gram-positive bacteria: the role of streptogramins and other newer compounds. Diagn Microbiol Infect Dis 1999; 33: 101–12.

Ballow CH Jones RN Biedenbach DJ . A multicenter evaluation of linezolid antimicrobial activity in North America. Diagn Microbiol Infect Dis 2002; 43: 75–83.