To describe the safety and efficacy of influenza vaccines in asthmatic children.
DATA SOURCES:
Literature was identified by a MEDLINE search (2002–March 2003). Key search terms included asthma, exacerbation, children, vaccine, and influenza.
DATA SYNTHESIS:
Concerns that the influenza vaccine may exacerbate asthma attacks have kept many asthmatic children from receiving this immunization. Researchers have conducted studies to determine the burden of influenza on asthmatic children, the safety of influenza vaccines, and their benefit in the presence of glucocorticoid burst therapy in the same population.
CONCLUSIONS:
Influenza vaccines tested are safe and efficacious in asthmatic children.
DipiroJTTalbertRLYeeGCMatzkeGRWellsBGPoseyLM, eds. Pharmacotherapy: a pathophysiologic approach. 5th ed. New York: McGraw-Hill, 2002:484.
2.
Centers for Disease Control and Prevention.Disabilities among children aged 17 years - United States, 1991-1992. MMWR Morb Mortal Wkly Rep1995;44:609–13.
3.
Centers for Disease Control and Prevention, National Health Interview Survey.New asthma estimates: tracking, prevalence, health care and mortality. Fact sheet. Atlanta: 10/5/01.
4.
Prevention and control of influenza recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep2000;49:1–38.
5.
GrantENWagnerRWeissKBObservations on emerging patterns of asthma in our society. J Allergy Clin Immunol1999;104:S1–9.
6.
NeuzilKMWrightPFMitchelEFJrGriffinMRThe burden of influenza illness in children with asthma and other chronic medical conditions. J Pediatr2000;137:856–64.
7.
TanakaYUedaKMiyazakiCNakayamaMKusuharaKOkadaKTrivalent cold recombinant influenza live vaccine in institutionalized children with bronchial asthma a patients with psychomotor retardation. Pediatr Infect Dis J1993;12:600–5.
8.
ReddingGWalkerREHesselCVirantFAyarsGHBenschGSafety and tolerability of cold-adapted influenza virus vaccine in children and adolescents with asthma. Pediatr Inf Dis J2002;21:44–8.
9.
The safety of inactivated influenza vaccine in adults and children with asthma. N Engl J Med2001;345:1529–36.
10.
FairchokMPTrementozziDPCarterPSRegneryHLCarterEREffect of prednisone on response to influenza virus vaccine in asthmatic children. Arch Pediatr Adolesc Med1998;152:1191–5.
