To review available literature regarding the use of divalproex sodium in the treatment of agitation in elderly patients with dementia.
DATA SOURCES:
Clinical trials and review articles were identified by MEDLINE search (1966 — March 2002).
DATA SYNTHESIS:
The literature provides information regarding the potential benefits and tolerability of divalproex sodium in the treatment of dementia-related agitation. This article analyzes 7 studies to better understand the role of divalproex sodium in the treatment of dementia.
CONCLUSIONS:
Divalproex sodium may offer a slight benefit to elderly patients suffering from dementia-related agitation. Until better-controlled trials demonstrate statistical significance and comparisons with established treatments are performed, practitioners should use divalproex sodium cautiously.
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