Abstract
Warfarin is an established treatment method for anticoagulating patients following diagnosis of deep vein thrombosis (DVT). We present a patient who was on rifampicin treatment for pruritis, secondary to primary biliary cirrhosis (PBC), who was diagnosed with a DVT post operatively. A therapeutic INR was not obtained following fourteen days of warfarin treatment due to a drug interaction with rifampicin. We review the use of rifampicin for pruritis in PBC and the mechanism of interaction between warfarin and rifampicin.
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