Restricted accessCase reportFirst published online 2009-9
Hereditary angioedema and pregnancy: successful management of recurrent and frequent attacks of angioedema with C1-inhibitor concentrate,danazol and tranexamic acid – a case report
Hereditary angioedema (HAE) is a rare but potentially life-threatening condition caused by deficiency of C1 esterase inhibitor. It is characterized by subcutaneous swelling in any part of the skin, gastrointestinal and respiratory tracts. We present the case of a pregnant woman with known HAE that deteriorated during pregnancy with frequent attacks that were managed successfully with danazol, tranexamic acid and regular intravenous administration of C1 esterase inhibitor.
StillerRJ, KaplanBM, AndreoliJWJr.Hereditary angioedema and pregnancy. Obstet and Gynecol1984;64:133–5
2.
TalaveraA, LarraonaJL, RamosJL, Hereditary angioedema: an infrequent cause of abdominal pain with ascites. Am J Gastroenterol1995;90:471–4
3.
PradaAE, ZahediK, DavisAE. Regulation of C1 inhibitor synthesis. Immunology1998;199:377–88
4.
JohnsonAM, AlperCA, RosenFS, CraigJM. C1 inhibitor: evidence for decreased hepatic synthesis in hereditary angioedema. Science1971;173:553–4
5.
GomplesMM, LockRJ, MorganJE, OsborneJ, BrownA, VirgoPF. A multi-centre evaluation of the diagnostic efficiency of serological investigations for C1 inhibitor deficiency. J Clin Pathol2002;55:145–7
6.
KaplanAP, GreavesMW. Angioedema. J Am Acad Dermatol2005;53:373–88
7.
PekdemirM, ErselM, AksayE, YanturalliS, AkturkA, KiyanS. Effective treatment of hereditary angioedema with fresh frozen plasma in an emergency department. J Emerg Med2007;33:137–9
8.
HermansC. Successful management with C1-inhibitor concentrate of hereditary angioedema attacks during two successive pregnancies: a case report. Arch Gynecol Obstet2007;276:271–6
