Chondromyxoid fibroma (CMF) is a rare benign bone tumor of chondroid origin that occurs mostly in the metaphyses of long bones. CMF can occasionally mimic a chondrosarcoma on CT, and the literature on the 18F-FDG PET/CT imaging characteristics of CMF tumors is limited. In the presented case, a large histologically proven CMF chest wall mass was initially misinterpreted as a chondrosarcoma. This case highlights a potential pitfall in the PET/CT evaluation of these rare benign bone tumors.
SakaizawaT, KondoR, YoshidaK, Chondromyxoid fibroma of the chest wall. Gen Thorac Cardiovasc Surg2009;57:315–7
2.
SchajowiczF, GallardoH. Chondromyxoid fibroma(fibromyxoid chondroma) of bone. A clinoco-pathological study of thirty-two cases. J Bone Joint Surg Br1971;53:198–216
3.
SakamotoA, TanakaK, MatsudaS, Chondromyxoid fibroma of the clavicle. J Orthop Sci2006;11:533–6
4.
LevineSM, LambiaseRE, PetchprapaCN. Cortical lesions of the tibia: characteristic appearances at conventional radiography. Radiographics2003;23:157–77
5.
WilsonAJ, KyriakosM, AckermanLV. Chondromyxoid fibroma: radiographic appearance in 38 cases and in a review of the literature. Radiology1991;179:513–8
6.
KohJS, ChungJH, LeeSY, Chondrosarcoma of the proximal femur with myxoid degeneration mistaken for chondromyxoid fibroma in a young adult. A case report. Acta Cytol2001;45:254–8
7.
KeelSB, BhanAK, LiebschNJ, Chondromyxoid fibroma of the skull base: a tumor which may be confused with chordoma and chondrosarcoma. A report of three cases and review of the literature. Am J Surg Pathol1997;21:577–82
8.
WuCT, InwardsCY, O'LaughlinS, Chondromyxoid fibroma of bone: a clinicopathologic review of 278 cases. Hum Pathol1998;29:438–46
9.
TakaoE, MoriokaH, YabeH, Chondromyxoid fibroma of the sternum. J Thorac Cardiovasc Surg2006;132:430–1
10.
YamaguchiT, DorfmanHD. Radiographic and histologic patterns of calcification in chondromyxoid fibroma. Skeletal Radiol1998;27:559–4
11.
AokiJ, WatanabeH, ShinozakiT, FDG PET of primary benign and malignant bone tumors: standardized uptake value in 52 lesions. Radiology2001;219:774–7
12.
HamadaK, TomitaY, KonishiE, FDG-PET evaluation of chondromyxoid fibroma of left ilium. Clin Nucl Med2009;34:15–7
13.
SchulteM, Brecht-KraussD, HeymerB, Grading of tumors and tumorlike lesions of bone: evaluation by FDG PET. J Nucl Med2000;41:1695–701
14.
MakisW, HickesonM, LisbonaR. Maffucci syndrome with extraosseous chondrosarcoma imaged with F-18 FDG PET-CT. Clin Nucl Med2010;35:29–31
15.
FeldmanF, van HeertumR, SaxenaC, 18FDG-PET applications for cartilage neoplasms. Skeletal Radiol2005;34:367–74
16.
BrennerW, ConradEU, EaryJF. FDG PET imaging for grading and prediction of outcome in chondrosarcoma patients. Eur J Nucl Med Mol Imaging2004;31:189–95
