We report the case of an 84-year-old man who presented with collapse secondary to hypoglycaemia and was found to have a hepatic Solitary Fibrous Tumour (SFT) secreting Insulin-like Growth Factor II (IGF-II). Solitary fibrous tumours of the liver are very rare tumours and have occasionally been described in association with hypoglycaemia. SFT's of other organs have been associated with production of IGF-II but to our knowledge however there are no reports of a SFT of the liver with confirmed IGF-II hypersecretion, and we suggest that this mechanism underlies the hypoglycaemia seen in this case.
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Glucocorticoid therapy suppresses abnormal secretion of big IGF II by NICTH.Teale and Marks. Clinical Endocrinology. Vol 49; 1998; pp 491–98.
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Solitary Fibrous tumour of the uterus producing high-molecular weight Insulin-like Growth Factor II and Associated with hypoglycaemia.Kasuko. International Journal of Gynaecological Pathology (2005) vol 24. pp 79–84.
