Co-existing human immunodeficiency virus (HIV) infection can alter the course and presentation of syphilis. Severe ocular manifestations and accelerated natural course of syphilis along with neurosyphilis may be associated with HIV infection. A 30-year-old man is described in whom syphilitic panuveitis and asymptomatic neurosyphilis served as a marker for HIV infection.
MusherD.M., HamillR.J., BaughnR.E.. Effect of human immunodeficiency virus infection (HIV) on the course of syphilis and on the response to treatment.Ann Intern Med1990; 113: 872–81
2.
BlockerM.E., LevineW.C., St LouisM.E.. HIV prevalence in patients with syphilis, United States.Sex Transm Dis2000; 27: 53–9
3.
GregoryN., SanchezM., BuchnessM.R.. The spectrum of syphilis in patients with human immunodeficiency virus infection.J Am Acad Dermatol1990; 22: 1061–7
4.
McLeishW.M., PulidoJ.S., HollandS., CulbertsonW.W., WinwardK.. The ocular manifestations of syphilis in the human immunodeficiency virus type-1 infected host.Ophthalmology1990; 97: 196–203
5.
JohnsD.R., TierneyM., FelsensteinD.. Alteration in the natural history of neurosyphilis by concurrent infection with the human immunodeficiency virus.N Engl J Med1987; 316: 1569–72
ShalabyI.A., DunnJ.P., SembaR.D., JabsD.A.. Syphilitic uveitis in human immunodeficiency virus infected patients.Arch Ophthalmol1997; 115: 469–73
10.
BrowningD.J.. Posterior segment manifestations of active ocular syphilis, their response to a neurosyphilis regimen of penicillin therapy and the influence of human immunodeficiency virus status on response.Ophthalmology2000; 107: 2015–23
11.
LevyJ.H., LissR.A., MaguireA.M.. Neurosyphilis and ocular syphilis in patients with concurrent human immunodeficiency virus infection.Retina1989; 9: 175–80
12.
BiswasJ., MadhavanH.N., GeorgeA.E., KumarasamyN., SolomonS.. Ocular lesions associated with HIV infection in India: a series of 100 consecutive patients evaluated at a referral center.Am J Ophthalmol2000; 129: 9–15
