We review the literature on hepatic involvement in patients with HIV and syphilis co-infection and describe a case of rapid progression to neurosyphilis and presumed gummatous syphilitic hepatitis in a patient newly diagnosed with HIV. To our knowledge, this is the first case of syphilitic hepatitis with gummas described in the HIV population.
JungNKummerleTBrengelmannSD. Liver involvement in HIV-infected patients diagnosed with syphilis. Infection2012; 40: 543–547.
2.
SinghAERomanowskiB. Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features. Clin Microbiol Rev1999; 12: 187–209.
3.
MusherDMHamillRJBaughnRE. Effects of human immunodeficiency virus (HIV) infection on the course of syphilis and on the response to treatment. Ann Intern Med1990; 113: 872–881.
4.
FloodJMWeinstockHSGuroyME. Neurosyphilis during the AIDS epidemic, San Francisco, 1985–1992. J Infect Dis1998; 177: 931–940.
5.
MarraCMMaxwellCLSmithSL. Cerebrospinal fluid abnormalities in patients with syphilis: association with clinical and laboratory features. J Infect Dis2004; 189: 369–376.
6.
VarmaRBaithunSAlexanderS. Acute syphilitic interstitial orchitis mimicking testicular malignancy in an HIV-infected man diagnosed by Treponema pallidum polymerase chain reaction. Int J STD AIDS2009; 20: 65–66.
7.
McVeyMCameronWMacPhersonP. When infections collide-gummatous syphilis in an HIV-infected individual. Int J Infect Dis2010; 14: e283–e286.
MaincentGLabadieHFabreM. Tertiary hepatic syphilis: a treatable cause of multinodular liver. Dig Dis Sci1997; 42: 447–450.
10.
SabbataniSManfrediRAttardL. Secondary syphilis presenting with acute severe hepatic involvement in a patient with undiagnosed HIV disease. AIDS Patient Care STDS2005; 19: 545–549.
11.
ManaviKDhasmanaDCrambR. Prevalence of hepatitis in early syphilis among an HIV cohort. Int J STD AIDS2012; 8: e4–e6.
12.
PalaciosRNavarroFNarankiewiczD. Liver involvement in HIV-infected patients with early syphilis. Int J STD AIDS2013; 24: 31–33.
