Abstract
During 15 years of inbreeding of pigs (Canadian Landrace) a semi-inbred line has been developed. The inbreeding coefficient (Fx) is 0·84, which theoretically corresponds to between 8-9 generations of brother/sister matings. At the highest inbreeding level (0·84) the mean number of newborn piglets in the litter was 7·2 (5 litters, n = 36) including 5 stillborn (13·8%). The mean birth weight of the litter was 8·56 kg (5 litters, n = 31) the mean piglet birth weight was 1·23 kg and at the age of 21 days the mean weight of a litter was 33·24 kg with a mean piglet weight of 5·44 kg. During inbreeding, immunogenetic alloantigenic systems were investigated. Of 15 known erythrocyte systems, alleles of loci J, K, and of the most polymorphic system E, segregated. As to other immunogenetic systems (histocompatibility, leucocyte and allotypes) 2 SLA haplotypes (major histocompatibility complex) and 2 alleles of the SLC leucocyte system segregated. Allotransplants of the skin in SLA compatible siblings survived for a mean of 50·7 days (n = 77) compared with 10·8 days (n = 29) in non-inbred siblings. Tests of blastic transformation activated by T and B lymphocyte mitogens revealed a normal cell-mediated immune response. After immunization with some cell membrane alloantigens a normal humoral response was also recorded. All tested animals were halothaneresistant and tolerated a 10-min exposure to 5% without developing malignant hyperthermia. Depression due to inbreeding was manifested by a reduced reproductive ability (smaller number of piglets, frequent incidence of gonadal hypoplasia, diminution or loss of libido).